"The Omicron variant...could be a game-changer: shortages of inputs and labour would worsen for manufacturers if Britain and other countries went into another lockdown," said Samuel Tombs at Pantheon Macroeconomics.
IHS Markit's final manufacturing Purchasing Managers' Index (PMI) for the euro zone nevertheless nudged up to 58.4 in November from October's 58.3, shy of an initial 58.6 "flash" estimate but still comfortably above the 50 mark separating growth from contraction.
Supply chain issues have made it a sellers' market for raw materials and the input prices index was only just below October's record high and factories in the region passed on the rising costs to customers at the fastest rate in the survey's history.
That suggests overall inflation in the bloc, which preliminary official data showed on Tuesday was a record high 4.9% last month, will continue to overshoot the European Central Bank's 2.0% target putting pressure on the bank to act.
In Britain, outside the European Union and euro zone, more manufacturers than at any point in the last 30 years reported rising costs last month, underlining pressure on the Bank of England to raise interest rates.
The BoE will be the first major central bank to raise interest rates, possibly as soon as this month, a November Reuters poll predicted.
U.S. central bankers will discuss in December whether to end their bond purchases a few months earlier than had been anticipated, Federal Reserve Chair Jerome Powell said on Tuesday, leading to a sharp move higher in shorter-dated Treasury yields.
China's factory activity fell back into contraction in November, the private Caixin/Markit Manufacturing PMI showed, as soft demand and elevated prices hurt manufacturers.
The findings from the private-sector survey, which focuses more on small firms in coastal regions, stood in contrast with those in China's official PMI on Tuesday that showed manufacturing activity unexpectedly rose in November, albeit at a very modest pace.
"Relaxing constraints on the supply side, especially the easing of the power crunch, quickened the pace of production recovery," said Wang Zhe, senior economist at Caixin Insight Group, in a statement accompanying the data release.
"But demand was relatively weak, suppressed by the COVID-19 epidemic and rising product prices."
Beyond China, however, factory activity seemed to be on the mend with PMIs showing expansion in countries ranging from Japan, South Korea, India, Vietnam and the Philippines.
Japan's PMI rose to a near four-year high while in South Korea's the edged up.
India's manufacturing activity grew at the fastest pace in 10 months in November, buoyed by a strong pick-up in demand. Taiwan's manufacturing activity continued to expand and it was a similar picture in Indonesia.
(Reporting by Jonathan Cable and Leika Kihara; Editing by Sam Holmes and Toby Chopra) ((firstname.lastname@example.org; +44 20 7513 4029;))