Spot gold was down 0.3 percent at $1,312.97 an ounce at 1002 GMT, while the dollar USD/ was slightly stronger against a basket of major currencies.
U.S. gold futures for April delivery were 0.4 percent lower at $1,312.50 an ounce.
"The market has fully priced in a rate hike," Saxo Bank analyst Ole Hansen said.
Investors were instead looking ahead to guidance on the pace of future rate increases, with the Fed likely to take a cautious approach that would help lift gold prices, he said.
"With inflation not really picking up, rising geopolitical risk, trade wars looming and a flattening yield curve - this is not a backdrop that gives the Fed any urgent need to step up the speed of rate hikes."
Markets expect the Fed to raise rates three or four times this year. Gold prices have tended to fall ahead of rate hikes in recent years and to rise after them.
As gold has fallen, funds have scaled back bets on higher prices, with the net long position in Comex gold falling to around 136,000 contracts from almost 210,000 in late January.
That gives investors more space to buy gold, which could help prices recover, MKS trader Sam Laughlin said.
Holdings of gold in exchange-traded funds (ETFs) tracked by Reuters have meanwhile jumped to the highest since November 2016.
"That tells me longer-term investors have not given up their belief in higher prices," Saxo Bank's Hansen said.
Technical support for gold was at its 100-day moving average of $1,305 an ounce.
In other precious metals, silver was down 0.1 percent at $16.28 an ounce, trading at three-month lows.
Platinum was down 0.5 percent at $948.30 an ounce after touching its lowest since Jan. 3 on Monday. Palladium was 0.2 percent lower at $987.97 an ounce.
(Additional reporting by Nithin Prasad and Eileen Soreng in Bengaluru; Editing by Dale Hudson) ((Peter.Hobson@thomsonreuters.com; +44 207 542 0083;))