Overnight, fixed income markets were the big movers, with some analysts pointing to a setback to more U.S. stimulus efforts, while others suggested a likely clearing out of short positions ahead of the May CPI.
Short positions in Treasuries were the highest since 2018, according to JP Morgan positioning data last week.
The yield on benchmark 10-year U.S. Treasury notes slipped to 1.4891% from 1.528% late on Tuesday. A fall below 1.47% would take yields to the lowest since March 4.
Also at play was some thought that hedge funds may have shifted their bond allocation, driven by lower volatility in the bond market recently, analysts said.
On Wall Street overnight, the S&P 500 came within a whisker of its all-time high set in May as big tech rallied along with healthcare stocks, but finished 0.1% lower. The Dow slipped 0.44% and the Nasdaq Composite fell 0.09%.
Markets are looking to the European Central Bank (ECB)policy meeting later in the day where it will likely keep its policy guidance unchanged and publish updated euro area macroeconomic projections.
Also later in the global day, expectations are that U.S. CPI will accelerate 0.4% in May, taking the annual pace to 3.4%, according to a Reuters Poll.
"A significant upside surprise in inflation could tilt the Fed taper discussion to sooner rather than later, though the majority would still be looking for substantial progress toward maximum employment before considering tapering," ANZ economists wrote in a note.
So far though, "the market is buying into the Fed's view that the rise in prices is transitory and the Fed will not alter its policy guidance at next week’s FOMC meeting," they added.
Analysts said the data would be key for gold as a higher print and the subsequent tapering fears could reduce the yellow metal's lustre.
U.S. gold futures eased 0.3% to $1,889.50 an ounce.
Oil prices slipped after rallying in the previous session on hopes of higher demand from western economies which are gradually reopening from coronavirus lockdowns.
Brent crude futures fell 22 cents to 72 a barrel, while U.S. crude futures were 27 cents lower at $69.69 a barrel.
Activity was muted in the currency market with the dollar flat against the yen at 109.58.
The euro was a tad weaker at $1.2169 ahead of the ECB meeting while the British pound eased to $1.4100. The Aussie and New Zealand dollar were a shade lower too.
That left the dollar index marginally firmer at 90.140.
(Reporting by Swati Pandey; editing by Richard Pullin) ((firstname.lastname@example.org; +61 2 9321 8166; Reuters Messaging: email@example.com; twitter.com/swatisays))