COPENHAGEN/ROME - Europe's choppy vaccine rollout hit more trouble on Wednesday after U.S. drugmaker Johnson & Johnson delayed its COVID-19 shot and Denmark said it would drop a similar vaccine from AstraZeneca over the risk of blood clotting.

The European Medicines Agency (EMA) was due to issue guidance on Johnson & Johnson later on Wednesday after U.S. federal health agencies recommended pausing use of the vaccine for at least a few days after six women under age 50 developed rare blood clots after receiving the shot.

Deliveries had already begun in some countries but authorities across the continent said they were suspending deployment or considering restricting use of the single-shot vaccine, pending further advice.

"The delivery of the J&J will take place, we will await the announcement of EMA and the FDA in the U.S.," Marios Themistocleous, the official in charge of Greece's pandemic response, said on state TV.

The delay came as a further blow to Europe's faltering vaccinations campaign, which has been hit by problems ranging from poor coordination between national and regional authorities to procurement difficulties and a damaging contractual row with British-Swedish drugmaker AstraZeneca.

"Here we are in the hands of God: if it goes right it goes right, if it goes wrong it goes wrong. I don't know, I don't know what to say," said Rome resident Annamaria Gingaroli.

Earlier this month, European regulators said they had found a possible link between AstraZeneca's COVID-19 vaccine and a similar rare blood clotting problem to the one connected to the Johnson & Johnson shot that led to a small number of deaths.

The EMA has recommended AstraZeneca's vaccine, saying the benefits outweigh the risks, but several EU countries have limited its use to certain age groups and on Wednesday, Danish authorities said they were dropping the AstraZeneca vaccine.

"The Danish Health Authority has decided to continue the vaccination against COVID-19 without the vaccine from AstraZeneca," it said in a statement. 

Although deliveries of the J&J shot had barely begun in Europe, questions about the two vaccines threaten to undermine public confidence in the low-cost jabs which authorities had been counting on as a central weapon in fighting a pandemic that has claimed more than 3 million lives.

An official from the U.S. Food and Drugs Administration (FDA) said it was "plainly obvious" the J&J cases were "very similar" to the AstraZeneca ones. He said no similar blood clot cases had been reported among recipients of the Moderna or Pfizer/BioNTech, vaccines, which use a different technology.

J&J has said it is working closely with regulators and noted no clear causal relationship had been established between the events and its shot.

AstraZeneca was not immediately available for comment on Wednesday. It has said in the past it is working to understand individual cases of side-effects and "possible mechanisms that could explain these extremely rare events".

French government spokesman Gabriel Attal told a news conference on Wednesday the government remained confident in the AstraZeneca shot.

CONTRACT

The potential risks with blood clots comes on top of an angry row between the European Commission and AstraZeneca, after the drugmaker delivered only a fraction of the vaccines ordered by Brussels.

Italian newspaper La Stampa reported that the Commission had decided not to renew COVID-19 vaccine contracts next year with AstraZeneca and J&J and would instead focus on vaccines using messenger RNA (mRNA) technology, such as Pfizer's and Moderna's. 

A spokesman for the EU Commission said it was keeping all options open for 2022 and beyond but declined to comment on the contracts.

The clotting issue has so far been confirmed to have affected only a handful of millions of people vaccinated with the shots, leaving authorities facing a difficult public health dilemma, exacerbated in many countries by widespread public suspicion of vaccines in general.

The FDA said there had been one reported death from the rare blood clotting condition among recipients of the J&J vaccine, while another person was in a critical condition.

An advisory committee to the U.S. Centers for Disease Control and Prevention is due to meet on Wednesday to review the six clotting cases and vote on recommendations for future use of the shot. The FDA will then review the analysis.

All six cases involved women between the ages of 18 and 48, with symptoms occurring six to 13 days after vaccination. The FDA said patients should watch for up to three weeks for symptoms including severe headache, abdominal pain, leg pain or shortness of breath.

In the six cases, a type of blood clot called cerebral venous sinus thrombosis (CVST) was seen in combination with low levels of blood platelets, or thrombocytopenia.

The J&J and AstraZeneca vaccines both use an adenovirus - a harmless cold virus - as a vector to deliver instructions for human cells to produce a protein found on the surface of the coronavirus, spurring the immune system to recognize and attack the actual virus.

(Reporting by Reuters bureaux; Writing by James Mackenzie; Editing by Nick Macfie)