KARACHI, Pakistan  - The Pakistani rupee continued to fall to record lows on Friday, after the government agreed in principle to a $6 billion loan from the International Monetary Fund that's expected to set tough conditions on Prime Minister Imran Khan's administration.

The rupee, which lost 3.6 percent on Thursday to close at 146.2 against the U.S. dollar in the interbank market, dropped further on Friday, dealers said, selling at 149.50 in the interbank market and 150 in the open market.

The fall reflects the IMF's condition for a "market-based exchange rate mechanism, which will see limited intervention by the central bank now," said Saad Hashemy, chief economist and research director at Topline Securities in Karachi.

Pakistan's stock market also declined on Friday, with the benchmark KSE 100 index down 2.4 percent by 0615 GMT.

While the exact conditions of a final IMF deal are still unknown, Sunday's Staff-Level accord, which must still be approved by the Fund's board in Washington, said a "market-determined" exchange rate would help the financial sector. That pointed to less support from the central bank, which at present underpins the rupee in a de facto managed float system.

Late on Thursday, the central bank issued a statement saying the sharp fall in the rupee "reflects demand and supply conditions in the foreign exchange market" and would help in correcting market imbalances.

However the drop presents a political problem for Khan's government, which came to power last year promising to build a new social welfare system and vowing not to seek what would be Pakistan's 13th bailout since the 1980s.

With the economy facing a sharp slowdown in growth, the government is expected to have to raise taxes or impose heavy spending cuts to reduce its ballooning budget deficit at a time when household budgets are increasingly squeezed.

While many analysts see the rupee as overvalued and say the central bank has wasted billions defending it, a weaker currency is likely to fuel inflation, which is already over 8 percent, with power and fuel prices hit especially hard.

Hashemy noted market talk that oil imports were already facing payment pressure.

The central bank, which is due to announce its latest interest rate decision on Monday, said late on Thursday that its foreign exchange reserves fell $138 million in the week ending May 10 to $8.846 billion, less than needed to cover three months of imports.

(Reporting by Syed Raza Hassan; Editing by Richard Borsuk) ((james.mackenzie@thomsonreuters.com; +92 300 8566 702 ; Reuters Messaging: Reuters Messaging james.mackenzie.reuters.com@reuters.net))